[DOWNLOAD] "Clinical Research Transformed" by Olli S. Miettinen, Johann Steurer & Albert Hofman * eBook PDF Kindle ePub Free

eBook details

Title: Clinical Research Transformed
Author : Olli S. Miettinen, Johann Steurer & Albert Hofman
Release Date : January 15, 2019
Genre: Medical,Books,Professional & Technical,Computers & Internet,Computers,Science & Nature,Life Sciences,
Pages : * pages
Size : 2153 KB

Description

This book delineates the fundamental transformations that, according to its precepts,are now needed in the objects and methods of ‘patient-oriented’ clinical research, inorder to make it genuinely patient-relevant. These transformations are presented asproviding for transition from today’s ‘evidence-based’ practices (advocated by ‘clinicalepidemiologists’) to knowledge-based succedanea of these. While those existingpractices vary according to doctors’ personal opinions about the burden of the availableevidence, their knowledge-based succedanea will be essentially invariant acrossindividual doctors, as they’ll be guided by ‘expert systems’ (imbedded in cyberspace). Atissue in this is transformation in what the authors present as the very essence of clinicalmedicine, namely clinical doctors’ esoteric ad-hoc knowing: “gnosis.” This is clinicaldoctors’ knowing — probabilistic — about relevant-but-hidden truths about their patients’health, and constitutes the basis for their teaching (“doctoring”) the patients about theseesoteric insights. The probabilities are ‘personalized’ in the meaning of their specificityto the cases’ gnostic profiles.
Genuinely patient-relevant clinical knowledge this book presents as the requisitebasis for three species of clinical doctors’ gnosis: diagnosis — knowing about whether aparticular type of illness is present (though hidden) in the patient; etiognosis — knowingabout whether the patient’s illness was caused by a particular antecedent of it; andprognosis — knowing about the patient’s future health, including as to its dependenceon the choice of treatment. Pivotal in gnostic clinical research this book presents to bethe studies’ objects design in terms of a statistical model for the rate of occurrence ofthe entity of health in question, in a defined domain of case presentations. Theessentials of the studies’ methods designs are deduced from their objects designs.
Study of this book — on the theory of “meta-epidemiological clinical research” — isessential preparation for teaching ‘patient-oriented’ clinical research and for actualdesign & conduct of the studies and of their critical reviews. And by the same token,study of this book is essential preparation for the needed replacement of ‘case-basedlearning’ of clinical medicine, for suitably-learned teaching of the practice of clinicalmedicine — focused on the status quo of the scientific knowledge-base for (gnoses in)the discipline (‘specialty’) at issue.